Goitre in South-West Nigeria           Orient Journal of Medicine      Vol 33[3-4] Jul-Dec, 2021
ORIGINAL ARTICLE

Characteristics and Blood Pressure Profile of Goitre Patients in A   Tertiary Hospital in South-West Nigeria

Adeola O AJIBARE1
Adekunle ADEYEMO2
Akinwumi O OLAKANMI3
Emmanuel Y FAGBEMIRO4
Ayoola S ODEYEMI5
Suraj A OGUNYEMI6
Rasaaq A ADEBAYO6
Babatope A KOLAWOLE6
Michael O BALOGUN6

1Department of Medicine
Faculty of Clinical Sciences 
Lagos State University College of Medicine Ikeja, Lagos, NIGERIA

2Department of Otorhinolaryngology
Faculty of Clinical Sciences
Obafemi Awolowo University
Ile-Ife, NIGERIA

3Department of Surgery
Faculty of Clinical Sciences
University of Medical Sciences
Ondo, NIGERIA

4Department of Medicine
Nile University Abuja, NIGERIA

5Renal Unit, Department of Medicine
General Hospital, Lagos Island
Lagos, NIGERIA

6Department of Medicine
Faculty of Clinical Sciences
OAU, Ile-Ife, NIGERIA

Author for Correspondence
Dr Adeola Olubunmi AJIBARE
Department of Medicine
Faculty of Clinical Sciences 
Lagos State University College of Medicine Ikeja, Lagos, NIGERIA

Phone: +234 803 325 1010
Email: adeola.ajibare@lasucom.edu.ng <mailto:adeola.ajibare@lasucom.edu.ng>

Received: December 30th, 2020
Accepted: March 8th, 2021

DISCLOSURE
Conflict of interest: None
Financial support: None
ABSTRACT

Background: Goitre remains endemic in iodine deficient areas of the world despite widespread introduction of iodine fortified food. In Nigeria, it is the second most common condition in endocrinology clinic. There is a therefore a need to document the blood pressure profile and clinical characteristics of this condition.
Objective:  This study assessed the clinical characteristics, biochemical and blood pressure profile of patients with goitre in the study area and assessed their knowledge and practice of preventive measures against goitre.
Methodology: A comparative study of 103 adults with goitres and 103 healthy controls. An interviewer administered questionnaire was used and venous blood samples were obtained for analyses. Variables of interest included socio-demographic, anthropometric, thyroid function, and blood pressure.
Results: The mean age of the goitre group was 46.92 13.85 years with 86.4% carrying the swelling for up to 5 years. Anthropometric parameters, social habits, knowledge, and practice of the preventive role of iodized salt were similar between the goitre and control groups.
Forty-six percent of the goitrous subjects were hyperthyroid. Weight and BMI were significantly higher among the hypothyroid subgroup (p<0.001), with subjects in the hyperthyroid subgroup having significantly higher pulse rate and systolic blood pressure (p<0.001). The hypothyroid subgroup had significantly higher diastolic blood pressure and lower pulse pressure (p< 0.001).
Conclusion: This study concluded that patients with hyperthyroidism and hypothyroidism were more likely to have elevated systolic and diastolic blood pressure, respectively. Routine cardiovascular status check is therefore important in goitrous patients.


Key words:
Goitre, Thyroid Disease, Euthyroidism, Hyperthyroidism, Hypothyroidism