Serum Magnesium and Eclampsia                  Orient Journal of Medicine                    Vol 31 [1-2] Jan-June, 2019
ORIGINAL ARTICLE

Comparative Evaluation of Serum Magnesium Level in Pre-eclamptic and Non Pre-eclamptic Women in a tertiary Hospital in Southern Nigeria  

Dennis O ALLAGOA
1 Okechukwu J AGBO1
Henry A UGBOMA2
Chituru G ORLUWENE2


1Federal Medical Centre Yenagoa, Bayelsa State NIGERIA


2University of Port Harcourt Teaching Hospital Port Harcourt, Rivers State NIGERIA

Author for Correspondence
Dr Dennis O ALLAGOA Federal Medical Centre Yenagoa Bayelsa State, NIGERIA

Phone: +234 803 338 8292 Email: denisallagoa@yahoo.com

Received: July 25th, 2018 Accepted: September 26th, 2018

DISLOSURE There was no conflict of interest declared and the study was self sponsored

ABSTRACT

Background:
Magnesium is a micronutrient found in the human body whose major function is to maintain nerve and muscle function. Magnesium sulphate has been used over time as a prophylactic drug in pre-eclamptic women. There is paucity of studies on the role of serum magnesium level in preeclampsia in South-South Nigeria.
Objective: The main objective of this study was to determine the serum levels of magnesium in cohorts of pre-eclamptic and non pre-eclamptic patients in a tertiary hospital in South-South Nigeria.
Methodology: This was a comparative study in which 104 women who satisfied the eligibility criteria were enrolled for the study (52 pre-eclamptic and 52 non- pre-eclamptic women). Data analysis was done using statistical software (IBM SPSS® for windows version 21.0.) Data was analyzed for mean and standard deviation. Comparison of serum levels of magnesium between the two groups was performed by student t-test and P value < 0.05 was considered as statistically significant.
Results: The study showed that the serum magnesium level was not statistically different between the pre-eclamptic and non-pre-eclamptic women (1.79±0.24mg/dl vs. 1.88±0.37mg/dl respectively, p = 0.10). There was no correlation between serum magnesium level and the systolic and diastolic blood pressures in either group.
Conclusion: This study showed that women with preeclampsia did not demonstrate reduced serum magnesium level. This support the hypothesis that hypomagnesaemia is not a possible aetiology of preeclampsia.


Key words:
Pregnancy, Micronutrients, Hypertension, Primigravida.